As a young girl, Lange was exposed to a plethora of literature and art. At the age of seven, she contracted polio, which left her with a partially paralyzed leg, and led her to walk with a limp for the rest of her life. Lange believed this was a turning point in her life. While speaking of her limp, Lange once said "It formed me, guided me, instructed me, helped me, and humiliated me."
Following the completion of a photography class at Columbia University with the famed photographer Clarence H. White, Lange began to make her way through the industry, creating personal connections with art patrons and artists. Soon thereafter, she moved to San Francisco, where she made a living by taking portraitures of the San Francisco elite. Despite her educational experience in photography, Lange was mostly self-taught. She trained and developed her personal style while trying to meet the demands of her wealthy subjects. Shortly after the Great Depression hit the United States, she began to feel dissatisfied with her work and took to the streets of San Francisco in an effort to document the financial hardships experienced by the residents of the city. It was then that she took her first documentary photograph, “White Angel Breadline”, which remains to be a symbol for the food shortage during the Great Depression.